CofC Logo

Mike Janech

Medical University of South Carolina

Address: 96 Jonathan Lucas St. 829 CSB - Nephrology, Charleston, SC 29425
Phone: 843.792.1083
E-mail: janechmg@musc.edu
Personal Website: http://clinicaldepartments.musc.edu/medicine/divisions/nephrology/faculty/janech.htm



Education

Ph.D., 2003, Medical University of South Carolina
M.S., 1998, College of Charleston


Research Interests

  • Using proteomics as a tool for biomarker discovery and to study regulatory pathways in marine organisms
  • Dolphin endocrinology

Current and planned research projects

  • proteomic approaches to understanding biogenic sulfur production in sea-ice diatoms
  • identifying plasma biomarkers of domoic acid toxicosis in California sea lions
  • identifying ice-binding proteins from psycrophilic algae
  • discovery of urine biomarkers in patients with glomerular disease

Publications

  • Neely BA, Soper JL, Gulland FMD, Bell PD, Kindy M, Arthur JM, and Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. In Press.
  • Neely BA, Ferrante JA, Chaves JM, Soper JL, Almeida JS, Arthur JM, Gulland FM, Janech MG. Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Comoic Acid Toxicosis. PLoS One. 2015 Apr 28;10(4):e0123295. PubMed PMID: 25919366.
  • Neely BA, Carlin KP, Arthur JM, McFee WE, Janech MG. Ratiometric Measurements  of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon. Front Endocrinol (Lausanne). 2013 Sep 20;4:132. doi: 10.3389/fendo.2013.00132. PubMed PMID: 24065958; PubMed Central PMCID: PMC3778387.
  • Venn-Watson S, Smith C, Stevenson S, Parry C, Daniels R, Baird M, Carlin K, Cendejas V,  Balmer B,  Janech MG, Neely BA, Wells R,. Blood-based indicators of insulin resistance and metabolic syndrome in bottlenose dolphins (Tursiops truncatus).Frontiers Endocrinology, 2013, vol. 4. Article 136. DOI:10.3389/fendo.2013.00136
  • Neely BA, Soper JL, Greig DJ, Carlin KP, Favre EG, Gulland FM, Almeida JS, Janech MG. Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions. Proteome Sci. 2012 Mar 19;10(1):18. doi: 10.1186/1477-5956-10-18. PubMed PMID: 22429742; PubMed Central  PMCID: PMC3338078.
  • Lyon BR, Lee PA, Bennett JM, DiTullio GR, Janech MG. Proteomic analysis of a sea-ice diatom: salinity acclimation provides new insight into the dimethylsulfoniopropionate production pathway. Plant Physiol. 2011 Dec;157(4):1926-41. doi: 10.1104/pp.111.185025. Epub 2011 Oct 27. PubMed PMID: 22034629; PubMed Central PMCID: PMC3327215.
  • Velez J.C., K.J. Ryan, C.E. Harbeson, C.L. Woodworth, A.M. Bland, M.N. Budisavljevic, J.M. Arthur, W.R. Fitzgibbon, J.R. Raymond, M.G. Janech. Angiotensin-1 is largely converted to angiotensin-(1-7) and angiotensin-(2-10) by isolated rat glomeruli. Hypertension, vol. 53, p. 790-797.