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Frank Marí

National Institute of Standards and Technology

Address: Hollings Marine Lab, 331 Fort Johnson Road, Charleston, SC 29412
Phone: 843.460.9895


Ph.D., 1990, University of Massachusetts, Amherst

Research Interests

  • Marine biochemistry

Current and planned research projects


  • Rodriguez, A. M., Dutertre, S., Lewis, R. J., and Marí, F. 2015. Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS. Analytical and bioanalytical chemistry, 407(20), 6105-6116
  • Heghinian, M. D., Mejia, M., Adams, D. J., Godenschwege, T. A., and Marí, F. 2015. Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins. The FASEB Journal, 29(3), 1011-1018
  • Franco, A., Kompella, S. N., Akondi, K. B., Melaun, C., Daly, N. L., Luetje, C. W., Alewood, P.F., Craik, D.J., Adams, D.J., and Marí, F. 2012. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochemical pharmacology, 83(3), 419-426
  • Akcan, M., Clark, R. J., Daly, N. L., Conibear, A. C., Faoite, A., Heghinian, M. D., Sahil, T., Adams, D.J., Marí, F., and Craik, D. J. 2015. Transforming conotoxins into cyclotides: Backbone cyclization of P‐superfamily conotoxins. Biopolymers: Peptide Science, 104(6), 682-692
  • Kompella, S. N., Hung, A., Clark, R. J., Marí, F., and Adams, D. J. 2015. Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. Journal of Biological Chemistry, 290(2), 1039-1048.
  • Mejia, M., Heghinian, M. D., Marí, F., and Godenschwege, T. A. 2013. New tools for targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster. PloS one, 8(5), e64685
  • Möller, C., Vanderweit, N., Bubis, J., and Marí, F. 2013. Comparative analysis of proteases in the injected and dissected venom of cone snail species. Toxicon, 65, 59-67
  • Mejia, M., Heghinian, M. D., Busch, A., Marí, F., and Godenschwege, T. A. 2012. Paired nanoinjection and electrophysiology assay to screen for bioactivity of compounds using the Drosophila melanogaster giant fiber system. Journal of visualized experiments: JoVE, (62)
  • Rivera-Ortiz, J. A., Cano, H., and Marí, F. 2011. Intraspecies variability and conopeptide profiling of the injected venom of Conus ermineus. Peptides, 32(2), 306-316.
  • Möller, C., Melaun, C., Castillo, C., Díaz, M. E., Renzelman, C. M., Estrada, O., Kuch, U., Lokey, S., and Marí, F. 2010. Functional hypervariability and gene diversity of cardioactive neuropeptides. Journal of Biological Chemistry, 285(52), 40673-40680
  • Mejia, M., Heghinian, M. D., Busch, A., Armishaw, C. J., Marí, F., Godenschwege, T. A. 2010. A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit. Toxicon, 56(8), 1398-1407
  • Möller, C., and Marí, F. 2011. 9.3 KDa components of the injected venom of Conus purpurascens define a new five‐disulfide conotoxin framework. Peptide Science, 96(2), 158-165