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Satomi Kohno

Assistant Professor, St. Cloud State University

Address: 217 ISELF Building, 720 4th Ave. South, St. Cloud, MN 56301
E-mail: skohno@stcloudstate.edu



Education

Ph.D., 2003, Yokohama City University, Yokohama, Japan


Research Interests

  • Endocrine alterations during embryonic development that cause serious health problems in later life – known as the developmental origins of adult disease – a critical research area of the National Institutes of Health.  Learning from the medical disaster of the DES (diethylstilbestrol, a synthetic estrogen) daughters, where in utero exposure led to serious reproductive diseases in later life such as vaginal and cervical cancer, endometriosis and breast cancer as well as urogenital abnormalities observed in DES sons.  The main research focus is to investigate endocrine-disrupting contaminants (EDCs) that alter endocrine signaling during development and lead to defects of the reproductive system.  Understanding the molecular mechanisms of endogenous and/or exogenous endocrine factors on the steroid hormone signaling system in a variety of vertebrates is the major focus of research.

Current and planned research projects

  • effects of steroid hormones or environmental contaminants on the sex determination and differentiation in the reproductive system in American alligators
  • environmental impacts on the sexual development, endocrine system and immune system in American alligators
  • comparative and molecular study of the steroid hormone receptors (e.g., estrogen receptor, retinoid X receptor) in a variety of vertebrates
  • evaluation of perinatal exposure to 17α-Hydroxyprogesterone caproate, a synthetic progestin using in the clinic, on the female reproductive system in mice

Publications

  • Toyota K, McNabb NA, Spyropoulos DD, Iguchi T, Kohno S. 2016 Toxic effects of chemical dispersant Corext 9500 on water flea Daphnia magna. J Appl Toxicol. doi: 10. 1002/jat.3343.
  • Yatsu R, Katsu Y, Kohno S, Mizutani T, Ogino Y, Ohta Y, Myburgh J, van Wyk JH, Guillette LJ Jr, Miyagawa S, Iguchi T. 2016 Characterization of evolutionary trend in squamate estrogen receptor sensitivity. Gen Comp Endocrinol. pii: S0016-6480(16)30080-6. soi: 10.1016/j.ygcen.2016.04.005.
  • McCoy KA, Roark AM, Boggs AS, Bowden JA, Cruze L, Edwards TM, Hamlin HJ, Cantu TM, McCoy JA, McNabb NA, Wenzel AG, Williams CE, Kohno S. 2016 Integrative and comparative reproductive biology: From alligators to xenobiotics. Gen Comp Endocrinol. pii: S0016-6480(16)30072-7. doi: 10.1016/j.ygcen.2016.03.026.
  • Doheny BM, Kohno S, Parrott BB, Guillette LJ Jr. 2016 In ovo treatment with an estrogen receptor alpha selective agonist causes precocious development of the female reproductive tract of the American alligator (Alligator mississippiensis). Gen Comp Endocrinol. pii: S0016-6480(16)30042-9. doi: 10.1016/j.ygcen.2016.02.026.
  • Yatsu R, Miyagawa S, Kohno S, Parrott BB, Yamaguchi K, Ogino Y, Miyakawa H, Lowers RH, Shigenobu S, Guillette LJ Jr, Iguchi T. 2016 RNA-seq analysis of the gonadal transcriptome during Alligator mississippiensis temperature-dependent sex determination and differentiation. BMC Genomics. doi: 10.1186/s 12864-016-2396-9.