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Gary Hardiman

Medical University of South Carolina

Address: 135 Cannon Street, Ste 303, MSC 835, Charleston, SC 29425
Phone: 843.792.0771
E-mail: hardiman@musc.edu



Education

Ph.D., 1993, National University of Ireland, Galway, Ireland


Research Interests

  • Computational marine genomics and genetics
  • Big Data science approaches to study Endocrine Disruption
  • Marine Systems Biology

Current and planned research projects

  • Marine mammas as sentinal species for human health: Resident dolphins accumulate extremely high levels of these chemicals, on the same order of magnitude as that of occupationally exposed humans. The objective is to advance our understanding of the effects of CECs on human health in coastal communities. The central hypothesis is that dolphins represent a worst-case model for human health risk assessment due to their constant CEC-exposure. They represent prime sentinels that can be exploited to provide spatial and temporal trends in CEC exposures and afford early warnings of adverse impacts in humans.
  • Big Data science approaches to study Endocrine Disruption: Endocrine disrupting compounds (EDCs), including personal care products (PCPs), can have significant effects on human health. The objective is to expand Big Data science approaches that integrate multidimensional, statistical and computational methods and provide expanded insights into how EDCs mediate their adverse effects.
  • Zebrafish as a model for studying EDC exposures: Zebrafish systems biology is advantageous in that it allows incorporation of dynamic effects such as differing concentrations of EDCs, homeostasis, temporal effects, developmental stage impacts, and whole embryo or tissue-specific analyses.

Publications

  • Maradonna F, Nozzi V, Dalla Valle L, Traversi I, Gioacchini G, Benato F, Colletti E, Gallo P, Di Marco Pisciottano I, Mita DG, Hardiman G, Mandich A, Carnevali O. A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles. Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov;166:1-13. doi: 10.1016/j.cbpc.2014.06.004. Epub 2014 Jun 27. PubMed PMID: 24981242.
  • Ribecco C, Hardiman G, Sášik R, Vittori S, Carnevali O. Teleost fish (Solea solea): a novel model for ecotoxicological assay of contaminated sediments. Aquat Toxicol. 2012 Mar;109:133-42. doi: 10.1016/j.aquatox.2011.12.002. Epub 2011 Dec 13. PubMed PMID: 22217502; PubMed Central PMCID: PMC3990034.
  • Gioacchini G, Giorgini E, Merrifield DL, Hardiman G, Borini A, Vaccari L, Carnevali O. Probiotics can induce follicle maturational competence: the Danio rerio case. Biol Reprod. 2012 Mar 8;86(3):65. doi: 10.1095/biolreprod.111.094243.Print 2012 Mar. PubMed PMID: 22088919; PubMed Central PMCID: PMC3316265.
  • Ribecco C, Baker ME, Šášik R, Zuo Y, Hardiman G, Carnevali O. Biological effects of marine contaminated sediments on Sparus aurata juveniles. Aquat Toxicol. 2011 Aug;104(3-4):308-16. doi: 10.1016/j.aquatox.2011.05.005. Epub 2011 May 13. PubMed PMID: 21658360.
  • Chen X, Li L, Cheng J, Chan LL, Wang DZ, Wang KJ, Baker ME, Hardiman G, Schlenk D, Cheng SH. Molecular staging of marine medaka: a model organism for marine ecotoxicity study. Mar Pollut Bull. 2011;63(5-12):309-17. doi:10.1016/j.marpolbul.2011.03.042. Epub 2011 Jun 25. PubMed PMID: 21708389.
  • Baker ME, Hardiman G. Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing. J Mol Endocrinol. 2014 Jun;52(3):R241-56. doi: 10.1530/JME-13-0219. Review. PubMed PMID: 24850832;PubMed Central PMCID: PMC4145605.
  • Vidal-Dorsch DE, Bay SM, Ribecco C, Sprague LJ, Angert M, Ludka C, Ricciardelli E, Carnevali O, Greenstein DJ, Schlenk D, Kelley KM, Reyes JA, Snyder S, Vanderford B, Wiborg LC, Petschauer D, Sasik R, Baker M, Hardiman G.Genomic and phenotypic response of hornyhead turbot exposed to municipal wastewater effluents. Aquat Toxicol. 2013 Sep 15;140-141:174-84. doi: 10.1016/j.aquatox.2013.05.017. Epub 2013 May 28. PubMed PMID: 23796538.
  • Baker ME, Vidal-Dorsch DE, Ribecco C, Sprague LJ, Angert M, Lekmine N, Ludka C, Martella A, Ricciardelli E, Bay SM, Gully JR, Kelley KM, Schlenk D, Carnevali O, Šášik R, Hardiman G. Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray. PLoS One. 2013 Sep 25;8(9):e75553. doi: 10.1371/journal.pone.0075553. eCollection 2013. PubMed PMID: 24086568; PubMed Central PMCID: PMC3783431.
  • Baker ME, Ruggeri B, Sprague LJ, Eckhardt-Ludka C, Lapira J, Wick I, Soverchia L, Ubaldi M, Polzonetti-Magni AM, Vidal-Dorsch D, Bay S, Gully JR, Reyes JA, Kelley KM, Schlenk D, Breen EC, Sásik R, Hardiman G. Analysis of endocrinedisruption in Southern California coastal fish using an aquatic multispecies microarray. Environ Health Perspect. 2009 Feb;117(2):223-30. doi: 10.1289/ehp.11627. Epub 2008 Aug 28. PubMed PMID: 19270792; PubMed Central PMCID:PMC2649224.
  • Reyes JA, Vidal-Dorsch DE, Schlenk D, Bay SM, Armstrong JL, Gully JR, Cash C, Baker M, Stebbins TD, Hardiman G, Kelley KM. Evaluation of reproductive endocrine status in hornyhead turbot sampled from Southern California's urbanized coastal environments. Environ Toxicol Chem. 2012 Dec;31(12):2689-700. doi: 10.1002/etc.2008. Epub 2012 Oct 16. PubMed PMID: 22987624.
  • Kim SH, Wu SY, Baek JI, Choi SY, Su Y, Flynn CR, Gamse JT, Ess KC, Hardiman G, Lipschutz JH, Abumrad NN, Rockey DC. A post-developmental genetic screen for zebrafish models of inherited liver disease. PLoS One. 2015 May 7;10(5):e0125980. doi: 10.1371/journal.pone.0125980. eCollection 2015. PubMed PMID: 25950913; PubMed Central PMCID: PMC4423964.
  • Xu EG, Mager EM, Grosell M, Pasparakis C, Schlenker LS, Stieglitz JD, Benetti D, Hazard ES, Courtney SM, Diamante G, Freitas J, Hardiman G, Schlenk D. Time- and Oil-Dependent Transcriptomic and Physiological Responses to Deepwater Horizon Oil in Mahi-Mahi (Coryphaena hippurus) Embryos and Larvae. Environ Sci Technol. 2016 Jul 19;50(14):7842-51. doi: 10.1021/acs.est.6b02205. Epub 2016 Jul 8. PubMed PMID: 27348429.
  • Maryoung LA, Lavado R, Bammler TK, Gallagher EP, Stapleton PL, Beyer RP, Farin FM, Hardiman G, Schlenk D. Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. Mar Biotechnol (NY). 2015 Dec;17(6):703-17. doi: 10.1007/s10126-015-9649-5. Epub 2015 Aug 11. PubMed PMID: 26260986; PubMed Central PMCID: PMC4636457.
  • Vidal-Dorsch DE, Bay SM, Greenstein DJ, Baker ME, Hardiman G, Reyes JA, Kelley KM, Schlenk D. Biological responses of marine flatfish exposed to municipal wastewater effluent. Environ Toxicol Chem. 2014 Mar;33(3):583-91. doi: 10.1002/etc.2466. Epub 2014 Jan 24. PubMed PMID: 24273037.