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Gary Hardiman

Medical University of South Carolina

Address: 135 Cannon Street, Ste 303, MSC 835, Charleston, SC 29425
Phone: 843.792.0771
E-mail: hardiman@musc.edu



Education

Ph.D., 1993, National University of Ireland, Galway, Ireland


Research Interests

  • Computational marine genomics and genetics
  • Big Data science approaches to study Endocrine Disruption
  • Marine Systems Biology

Current and planned research projects

  • Marine mammas as sentinal species for human health: Resident dolphins accumulate extremely high levels of these chemicals, on the same order of magnitude as that of occupationally exposed humans. The objective is to advance our understanding of the effects of CECs on human health in coastal communities. The central hypothesis is that dolphins represent a worst-case model for human health risk assessment due to their constant CEC-exposure. They represent prime sentinels that can be exploited to provide spatial and temporal trends in CEC exposures and afford early warnings of adverse impacts in humans.
  • Big Data science approaches to study Endocrine Disruption: Endocrine disrupting compounds (EDCs), including personal care products (PCPs), can have significant effects on human health. The objective is to expand Big Data science approaches that integrate multidimensional, statistical and computational methods and provide expanded insights into how EDCs mediate their adverse effects.
  • Zebrafish as a model for studying EDC exposures: Zebrafish systems biology is advantageous in that it allows incorporation of dynamic effects such as differing concentrations of EDCs, homeostasis, temporal effects, developmental stage impacts, and whole embryo or tissue-specific analyses.

Publications

  • Huff M, da Silveira WA, Carnevali O, Renaud L, Hardiman G. Systems Analysis ofthe Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer(2-Ethylhexyl) Phthalate (DEHP). Sci Rep. 2018 Feb 1;8(1):2118. doi:10.1038/s41598-018-20266-8. PubMed PMID: 29391432; PubMed Central PMCID:PMC5794889.
  • Api M, Bonfanti E, Lombardo F, Pignalosa P, Hardiman G, Carnevali O. Effectsof age on growth in Atlantic bluefin tuna (Thunnus thynnus). Gen Comp Endocrinol.2018 Jan 12. pii: S0016-6480(17)30718-9. doi: 10.1016/j.ygcen.2018.01.010. [Epubahead of print] PubMed PMID: 29339181.
  • Renaud L, Silveira WAD, Hazard ES, Simpson J, Falcinelli S, Chung D, CarnevaliO, Hardiman G. The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: ASystems Level Analysis of the miRNome. Genes (Basel). 2017 Oct 13;8(10). pii:E269. doi: 10.3390/genes8100269. PubMed PMID: 29027980; PubMed Central PMCID:PMC5664119.
  • Xu EG, Khursigara AJ, Magnuson J, Hazard ES, Hardiman G, Esbaugh AJ, RobertsAP, Schlenk D. Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure toWeathered Deepwater Horizon Crude Oil: Developmental and TranscriptomicConsequences. Environ Sci Technol. 2017 Sep 5;51(17):10162-10172. doi:10.1021/acs.est.7b02037. Epub 2017 Aug 18. PubMed PMID: 28768411.
  • Xu EG, Mager EM, Grosell M, Stieglitz JD, Hazard ES, Hardiman G, Schlenk D.Developmental transcriptomic analyses for mechanistic insights into criticalpathways involved in embryogenesis of pelagic mahi-mahi (Coryphaena hippurus).PLoS One. 2017 Jul 10;12(7):e0180454. doi: 10.1371/journal.pone.0180454.eCollection 2017. PubMed PMID: 28692652; PubMed Central PMCID: PMC5503239.
  • Soloff AC, Wolf BJ, White ND, Muir D, Courtney S, Hardiman G, Bossart GD, FairPA. Environmental perfluorooctane sulfonate exposure drives T cell activation inbottlenose dolphins. J Appl Toxicol. 2017 Sep;37(9):1108-1116. doi:10.1002/jat.3465. Epub 2017 Apr 19. PubMed PMID: 28425113; PubMed Central PMCID:PMC5831401.
  • Xu EG, Mager EM, Grosell M, Hazard ES, Hardiman G, Schlenk D. Noveltranscriptome assembly and comparative toxicity pathway analysis in mahi-mahi(Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil. SciRep. 2017 Mar 15;7:44546. doi: 10.1038/srep44546. PubMed PMID: 28295044; PubMedCentral PMCID: PMC5353654.
  • Xu EG, Mager EM, Grosell M, Pasparakis C, Schlenker LS, Stieglitz JD, BenettiD, Hazard ES, Courtney SM, Diamante G, Freitas J, Hardiman G, Schlenk D. Time-and Oil-Dependent Transcriptomic and Physiological Responses to Deepwater HorizonOil in Mahi-Mahi (Coryphaena hippurus) Embryos and Larvae. Environ Sci Technol.2016 Jul 19;50(14):7842-51. doi: 10.1021/acs.est.6b02205. Epub 2016 Jul 8. PubMedPMID: 27348429.
  • Maradonna F, Nozzi V, Dalla Valle L, Traversi I, Gioacchini G, Benato F, Colletti E, Gallo P, Di Marco Pisciottano I, Mita DG, Hardiman G, Mandich A, Carnevali O. A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles. Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov;166:1-13. doi: 10.1016/j.cbpc.2014.06.004. Epub 2014 Jun 27. PubMed PMID: 24981242.
  • Ribecco C, Hardiman G, Sášik R, Vittori S, Carnevali O. Teleost fish (Solea solea): a novel model for ecotoxicological assay of contaminated sediments. Aquat Toxicol. 2012 Mar;109:133-42. doi: 10.1016/j.aquatox.2011.12.002. Epub 2011 Dec 13. PubMed PMID: 22217502; PubMed Central PMCID: PMC3990034.