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Lou Guillette

Medical University of South Carolina

Address: Marine Biomedicine & Environmental Sciences, 221 Fort Johnson Road, Charleston, SC 29412
Phone: 843.876.2051


Ph.D., 1981, University of Colorado

Research Interests

  • vertebrate reproductive biology with an emphasis on developmental genetics and endocrine physiology; environmental health of wildlife and human populations with an emphasis on ecotoxicology and endocrine disrupting contaminants (EDCs)

Current and planned research projects

  • discovery of new EDCs that alter gene expression of the reproductive system
  • the genetics of sex determination in the American alligator
  • evolution of the reproductive system in vertebrates
  • developmental origins of adult disease, specifically contaminant induced alteration in the functioning of the ovary and fertility


  • Kohno, S, Y. Katsu, H. Urushitani, T. Iguchi and L.J. Guillette Jr.  2010.  Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.  Sexual Development 4:73-87. PMID:19940440
  • Moore, B.C., M. R. Milnes, S. Kohno, Y. Katsu, T. Iguchi and L.J. Guillette Jr.  2010.  Influences of sex, incubation temperature, and environmental quality on gonadal estrogen and androgen steroid receptor mRNA expression in juvenile American alligators (Alligator mississippiensis).  Biology of Reproduction 82: 194-201. PMID:19759368
  • Katsu, K., S. Kohno, H. Narita, H. Urushitani, X. Yamane, A. Hara, L.J. Guillette Jr. and Taisen Iguchi.  2010.  Cloning and functional characterization of Chondrichthyes, cloudy catshark, Scyliorhinus torazame and whale shark,Rhincodon typus estrogen receptors.  General and Comparative Endocrinology 168: 496-504. PMID:20600039
  • Hamlin, H., R. Lowers, and L.J. Guillette Jr.  2011.  Seasonal and ontogenic variation in concentrations of plasma androgens in male alligators from a barrier island population – Merritt Island National Wildlife Refuge.  Biology of Reproduction 85: 1108-1113. PMID:21816848
  • Hamlin, H.J. and L.J. Guillette Jr. 2011.  Embryos as targets of endocrine disrupting contaminants in wildlife. Birth Defects Res. (Part C) 93: 19-33. PMID:21425439